Fkbp4 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comFkbp4 Polyclonal Antibody for Mouse(Mus musculus)

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Fkbp4 (Gene name),

Peptidyl-prolyl cis-trans isomerase FKBP4 (Protein name ), FKBP4_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Fkbp4(Fkpb52);

Protein name:

Peptidyl-prolyl cis-trans isomerase FKBP4(PPIase FKBP4);

Alternative:

59 kDa immunophilin(p59);52 kDa FK506-binding protein(52 kDa FKBP;FKBP-52);FKBP59;FK506-binding protein 4(FKBP-4);Immunophilin FKBP52;HSP-binding immunophilin(HBI);Rotamase;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer (By similarity). Associates with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with NR3C1 and dynein (By similarity). Interacts with HSF1 in the HSP90 complex (By similarity). Associates with tubulin (By similarity). Interacts with MAPT/TAU (By similarity). Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent (By similarity). Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction.

Function:

Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening (By similarity). Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.

Subcellular Location:

Cytoplasm cytosol Nucleus Cytoplasm cytoskeleton

Protein Attributes:

Sequence length:

458

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

458:

QSRVETEA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P30416

KEGG:

mmu:14228

Pfam:

PF00254

UniGene:

Mm.12758

SMR:

P30416

Uniprot:

P30416

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ELISA Kit for Mouse PPIase FKBP4

Cat.:

E11170h

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96T

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ELISA Kit for Mouse PPIase FKBP4

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ELISA Kit for Mouse PPIase FKBP4

Cat.:

E11170m

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Packing:

96T

ELISA Kit for Mouse PPIase FKBP4

Cat.:

E11170r

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96T

ELISA Kit for Mouse PPIase FKBP4

Cat.:

E11170b

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Packing:

96T

CLIA Kit for Mouse PPIase FKBP4

Cat.:

U11170r

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Packing:

96T

CLIA Kit for Mouse PPIase FKBP4

Cat.:

U11170m

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Packing:

96T

CLIA Kit for Mouse PPIase FKBP4

MSDS:

Please sign in first.

CLIA Kit for Mouse PPIase FKBP4

Cat.:

U11170b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PPIase FKBP4

Cat.:

U11170h

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Manual:

Looking for manual.

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96T

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Polyclonal Antibody for Mouse PPIase FKBP4

Cat.:

P11170Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse PPIase FKBP4

Cat.:

P11170Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse PPIase FKBP4

Cat.:

P11170Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse PPIase FKBP4

Protein for Mouse PPIase FKBP4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor."
Schmitt J. , Stunnenberg H.G.
Gene132:267-271(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Embryo.
tissue: Spinal ganglion.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung tumor.
4.

"Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein."
Alnemri E.S. , Fernandes-Alnemri T. , Nelki D.S. , Dudley K. , Dubois G.C. , Litwack G.
Proc. Natl. Acad. Sci. U.S.A.90:6839-6843(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-458;PARTIAL PROTEIN SEQUENCE;FUNCTION;SUBCELLULAR LOCATION
strain: C57BL/6J.
tissue: Testis.
5.

"Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin."
Silverstein A.M. , Galigniana M.D. , Chen M.S. , Owens-Grillo J.K. , Chinkers M. , Pratt W.B.
J. Biol. Chem.272:16224-16230(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH NR3C1 AND HSP90AA1
6.

"Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus."
Galigniana M.D. , Radanyi C. , Renoir J.-M. , Housley P.R. , Pratt W.B.
J. Biol. Chem.276:14884-14889(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INTRACELLULAR TRAFFICKING;IDENTIFICATION IN A COMPLEX WITH HSP90AA1 AND NR3C1;INTERACTION WITH DYNEIN
7.

"A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins."
Davies T.H. , Ning Y.M. , Sanchez E.R.
J. Biol. Chem.277:4597-4600(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INTRACELLULAR TRAFFICKING;IDENTIFICATION IN A COMPLEX WITH HSP90AA1 AND NR3C1;SUBCELLULAR LOCATION;INTERACTION WITH DYNEIN
8.

Lubec G. , Yang J.W. , Zigmond M.
Submitted (2007-07) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 235-244
tissue: Brain.

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